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Association between Central Nervous System Drugs and Femoral Fracture Risk in Punjabi Population.

JSCCR




Dr. Jaskaran Singh,1  Dr. Abhimanu Kumar2,  Dr. B.K Aggarwal3

1)    Dr. Jaskaran Singh, MBBS (Batch 2016-2021) from Maharishi Markandeswar Institute of Medical Science and Research, Mullana, Ambala

2)    Dr. Abhimanu Kumar, Assistant Professor, Department of Anatomy, Ram Krishna Medical College Hospital and Research Centre

3)    Dr. B.K Aggarwal, Professor, Department of General Medicine & Principal of Maharishi Markandeswar Institute of Medical Science and Research, Mullana, Ambala, Haryana, India.


Abstract

Background: Femoral fractures are a significant health concern for elderly populations, and certain medications may contribute to this risk. This study investigates the association between the use of central nervous system (CNS) drugs and femoral fracture risk in individuals aged 80 and above in Punjabi.

Methods: A case-crossover design was employed, analyzing data from the Punjabi administrative claims database. Patients diagnosed with femoral neck fractures between 2016 and 2021 were identified (cases). Control periods were defined as 31-39 days before the fracture date. Daily intake of CNS drugs (categorized by Anatomical Therapeutic Chemical codes) during these periods was assessed. Conditional logistic regression was used to analyze the association between CNS drug use and fracture risk.

Results: The study included 5000 patients. Those taking CNS drugs exhibited a notably increased risk of femoral fracture compared to non-users. The odds ratios for fracture risk increased with the number of CNS drugs used, ranging from 3.41 for 1 drug to 4.34 for 3 or more drugs (all statistically significant).

Conclusion: This study suggests a strong association between the concomitant use of CNS drugs and an increased risk of femoral fractures in elderly individuals (80+) in Punjabi. Further research is needed to explore the underlying mechanisms and inform medication management strategies for this population.

Keyword: Nervous, System, Drugs, Femoral, Fracture, Population

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