Personalized Metformin Therapy for Local Communities.

Research Title by Research Scholar:

Evaluation of Genetic Polymorphisms Affecting the Efficacy and Safety of Metformin in Type 2 Diabetes Mellitus Patients of Eastern India

Project Duration: 12 Months

1. Project Background

Type 2 Diabetes Mellitus (T2DM) has reached epidemic proportions in India, with the Eastern region showing a rising prevalence. While Metformin remains the "gold standard" first-line treatment due to its cost-effectiveness and efficacy, clinical reality shows that not all patients respond to it equally. A significant number of patients experience either suboptimal glucose control or adverse gastrointestinal side effects, leading to treatment non-compliance and disease progression.

2. The Scientific Rationale

Recent advances in pharmacogenomics reveal that our genetic makeup—specifically genetic polymorphisms—dictates how our bodies process and respond to medication. In the ethnically diverse population of Eastern India, specific genetic variations can significantly alter the efficacy and safety profile of Metformin. By identifying these biomarkers, we move away from a "trial-and-error" approach toward a more precise, data-driven medical model.

3. The CSR Vision

Project GenEvolve is a pioneering CSR initiative designed to bridge the gap between high-end genomic research and grassroots healthcare. Our goal is to move beyond conventional treatment by introducing Personalized Medicine to local communities. By understanding the unique genetic landscape of patients in Eastern India, this project seeks to:

• Maximize Treatment Efficacy: Ensuring patients receive the most effective dosage based on their genetic profile.

• Minimize Adverse Risks: Reducing the burden of side effects that often lead to patients abandoning their medication.

• Promote Health Equity: Bringing cutting-edge diagnostic insights to underserved populations who otherwise lack access to personalized care.

  
  

4. Expected Impact

Through this study, we aim to develop a "Precision Care Framework" for T2DM management. This will not only improve the quality of life for thousands of patients in Eastern India but also reduce the long-term economic burden of diabetes-related complications on families and the healthcare system.